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  • Title: Biotransformations of steroid compounds by Chaetomium sp. KCH 6651.
    Author: Janeczko T, Dmochowska-Gładysz J, Kostrzewa-Susłow E, Białońska A, Ciunik Z.
    Journal: Steroids; 2009 Aug; 74(8):657-61. PubMed ID: 19463686.
    Abstract:
    Biotransformations of steroid compounds: androstenedione, testosterone, progesterone, pregnenolone and DHEA using Chaetomium sp. 1 KCH 6651 strain as a biocatalyst were investigated. The microorganism proved capable of selective hydroxylation of the steroid substrates. Androstenedione was converted to 14alpha-hydroxyandrost-4-en-3,17-dione (in over 75% yield) and 6beta-hydroxyandrost-4-en-3,17-dione (in low yield), while testosterone underwent regioselective hydroxylation at 6beta position. Progesterone was transformed to a single product-6beta,14alpha-dihydroxypregnan-4-en-3,20-dione in high yield, whereas biotransformation of DHEA resulted in the formation of 7alpha-hydroxy derivative, which was subsequently converted to 7alpha-hydroxyandrost-4-en-3,17-dione.
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