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  • Title: Distinguishing between primary infection and reinfection with rubella vaccine virus by IgG avidity assay in pregnant women.
    Author: Hamkar R, Jalilvand S, Abdolbaghi MH, Jelyani KN, Esteghamati A, Hagh-goo A, Mohktari-Azad T, Nategh R.
    Journal: East Mediterr Health J; 2009; 15(1):94-103. PubMed ID: 19469431.
    Abstract:
    During the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity anti-rubella IgG and were regarded as cases of reinfection.
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