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  • Title: Merobatzelladines A and B, anti-infective tricyclic guanidines from a marine sponge Monanchora sp.
    Author: Takishima S, Ishiyama A, Iwatsuki M, Otoguro K, Yamada H, Omura S, Kobayashi H, van Soest RW, Matsunaga S.
    Journal: Org Lett; 2009 Jun 18; 11(12):2655-8. PubMed ID: 19469518.
    Abstract:
    Merobatzelladines A (1) and B (2) have been isolated from a marine sponge Monanchora sp. as antibacterial constituents. Their structures including relative stereochemistry were determined by interpretation of spectral data. The absolute stereochemistry of merobatzelladine B (2) was elucidated after introduction of the fourth ring system preinstalled with a secondary hydroxyl group to which the modified Mosher method was applied. Merobatzelladines exhibit moderate anti-infective activity against a bacterium and protozoa.
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