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  • Title: Nicardipine versus salbutamol in the treatment of premature labor: comparison of their efficacy and side effects.
    Author: Trabelsi K, Hadj Taib H, Amouri H, Abdennadheur W, Ben Amar H, Kallel W, Zribi A, Gargouri A, Guermazi M.
    Journal: Tunis Med; 2008 Jan; 86(1):43-8. PubMed ID: 19472699.
    Abstract:
    THE OBJECTIVE: To compare the tocolytic action and the side effects of nicardipine to those of salbutamol in patients presenting premature labor in order to propose nicardipine as a promising alternative to salbutamol in the treatment of premature labor. METHODS: forty eight patients admitted for premature labor were included in this prospective randomized study comparing nicardipine and salbutamol, administered with intra venous drip. The nicardipine group included 25 patients and the salbutamol group included 23 patients. RESULTS: the epidemiologic characteristics of the 2 groups are similar. No significant difference between the 2 groups was noted in the average time of disappearance of the uterine contractions. In nicardipine group, the pregnancy was prolonged more than 48 hours in 87.5% of the cases against 85.8% in salbutamol group (P: NS). Adverse effects linked to tocolysis were recorded. In nicardipine group, 8% of the patients presented an intolerance of the molecule, against 47% of salbutamol group, the difference is significant (P = 0.02). The term of delivery was similar in both groups The neonatal status of the infants was identical in the two groups. In the group of new born hospitalized, we did not note biological disorders concerning the glycemia and the calcemy. CONCLUSION: nicardipine is at least as effective as salbutamol in tocolysis; but it has lest secondary effects. Thus, nicardipine is proposed as the tocolytic of first intention instead of the salbutamol which is considered as reference molecule.
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