These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: 2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.
    Author: El Bakali J, Klupsch F, Guédin A, Brassart B, Fontaine G, Farce A, Roussel P, Houssin R, Bernier JL, Chavatte P, Mergny JL, Riou JF, Hénichart JP.
    Journal: Bioorg Med Chem Lett; 2009 Jul 01; 19(13):3434-8. PubMed ID: 19473838.
    Abstract:
    The design and synthesis of 2,6-diphenylthiazolo[3,2-b][1,2,4]triazoles characterized by a large aromatic building block bearing cationic side chains are reported. These molecules are evaluated as telomeric G-quadruplex stabilizers and for their selectivity towards duplex DNA by competition experiments. Two compounds (14a, 19) were found active with high selectivity for telomeric G-quadruplex over duplex DNA.
    [Abstract] [Full Text] [Related] [New Search]