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  • Title: [The recurrence of duodenal ulcer in patients undergoing treatment with ranitidine and placebo. A multicenter study].
    Author: Villalobos JJ, Nava AA, Elizondo J, Gallo S, Guerrero C, Vargas F, Barrera A, Centeno F, Marín E, Peña F.
    Journal: Rev Gastroenterol Mex; 1991; 56(2):65-9. PubMed ID: 1947617.
    Abstract:
    This randomised, double-blind multicenter study was conducted in order to evaluate the long-term effect (one year) of 150 mg ranitidine vs placebo in 51 patients with healed duodenal ulcer. Seventeen patients had ulcer recurrence at the end of follow-up, one among the 24 patients that received ranitidine and 16 among the 27 patients that received placebo (p = 0.00009). No side effects was detected. Our results support the usefulness of a one-year maintenance therapy with 150 mg ranitidine.
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