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  • Title: Drug hypersensitivity syndrome induced by meglumine antimoniate.
    Author: Jeddi F, Caumes E, Thellier M, Jauréguiberry S, Mazier D, Buffet PA.
    Journal: Am J Trop Med Hyg; 2009 Jun; 80(6):939-40. PubMed ID: 19478253.
    Abstract:
    We report a case of drug hypersensitivity syndrome (drug reaction with eosinophilia and systemic symptoms [DRESS]) induced by parenteral meglumine antimoniate (Glucantime) in a 40-year-old man who traveled to Bolivia and was treated for mucocutaneous leishmaniasis. Two weeks after starting therapy, the patient had fever, joint pain, a cutaneous eruption, and hypereosinophilia (1,358 cells/mm(3)). These symptoms resolved after drug withdrawal but reappeared upon reintroduction of the drug. Pentavalent antimonials should be definitively withdrawn in patients with hypereosinophilia > 1,000 cells/mm(3) accompanied by systemic manifestations consistent with DRESS.
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