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  • Title: Optimized lipase-catalyzed synthesis of adipate ester in a solvent-free system.
    Author: Chaibakhsh N, Abdul Rahman MB, Abd-Aziz S, Basri M, Salleh AB, Abdul Rahman RN.
    Journal: J Ind Microbiol Biotechnol; 2009 Sep; 36(9):1149-55. PubMed ID: 19479288.
    Abstract:
    Immobilized Candida antarctica lipase-catalyzed esterification of adipic acid and oleyl alcohol was investigated in a solvent-free system (SFS). Optimum conditions for adipate ester synthesis in a stirred-tank reactor were determined by the response surface methodology (RSM) approach with respect to important reaction parameters including time, temperature, agitation speed, and amount of enzyme. A high conversion yield was achieved using low enzyme amounts of 2.5% w/w at 60 degrees C, reaction time of 438 min, and agitation speed of 500 rpm. The good correlation between predicted value (96.0%) and actual value (95.5%) implies that the model derived from RSM allows better understanding of the effect of important reaction parameters on the lipase-catalyzed synthesis of adipate ester in an organic solvent-free system. Higher volumetric productivity compared to a solvent-based system was also offered by SFS. The results demonstrate that the solvent-free system is efficient for enzymatic synthesis of adipate ester.
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