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  • Title: Synthesis and antinociceptive activity of pyrazolyl isoxazolines and pyrazolyl isoxazoles.
    Author: Karthikeyan K, Veenus Seelan T, Lalitha KG, Perumal PT.
    Journal: Bioorg Med Chem Lett; 2009 Jul 01; 19(13):3370-3. PubMed ID: 19481931.
    Abstract:
    Pyrazolyl isoxazolines and isoxazoles were synthesised in moderate to good yields using 1,3-dipolar cycloaddition of pyrazole derived nitrile oxide with various dipolarophiles such as N-substituted maleimide, diethylacetylene dicarboxylate and phenylacetylene. The synthesized compounds were evaluated for antinociceptive activities. The 3-pyrazolyl-4,5-dicarbethoxy isoxazoles (9a-c) exhibited the maximum antinociceptive activity.
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