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  • Title: Effect of early malnutrition and environmental stimulation in the performance of rats in the elevated plus maze.
    Author: Pereira-da-Silva MS, Cabral-Filho JE, de-Oliveira LM.
    Journal: Behav Brain Res; 2009 Dec 14; 205(1):286-9. PubMed ID: 19482048.
    Abstract:
    Malnourished rats since birth (mothers fed on 6% of protein) or controlled ones (16% of protein), half of each group received environmental stimulation (ES) from the age of 0-35th day, were studied. The performance in the elevated plus maze (EPM) was assessed on the last day. ES increased time spent and also the entries into open arms of EPM, but malnourished non-stimulated rats visited more segments near the central area than the distant ones. Data suggests an anxiolytic effect of ES which is less evident in malnourished rats.
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