These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hepatosplanchnic ischemia/reperfusion is a major determinant of lung vascular injury after aortic surgery.
    Author: Cornet AD, Kingma SD, Trof RJ, Wisselink W, Groeneveld AB.
    Journal: J Surg Res; 2009 Nov; 157(1):48-54. PubMed ID: 19482316.
    Abstract:
    OBJECTIVES: To study risk factors, including the level of cross-clamping and ischemia/reperfusion, for lung vascular injury after aortic surgery. DESIGN: Single-center prospective observational study. PATIENTS AND METHODS: Twenty-seven consecutive and mechanically ventilated patients were included within 3 h after elective aortic surgery, i.e., surgery on the thoracoabdominal aorta supported by left atrial to femoral bypass (n = 3), surgery on the suprarenal aorta (n = 5), surgery on the infrarenal aorta (n = 15), and reconstructions of the celiac and mesenteric arteries (n = 4). The (67)Gallium (Ga)-transferrin pulmonary leak index (PLI) served as a measure of lung vascular injury. RESULTS: The PLI was elevated (> or =14.1 x 10(-3)/min) in 74% of all patients and more so in patients undergoing suprarenal aortic surgery or reconstruction of celiac and mesenteric arteries than in the patients undergoing the other types of surgery (P = 0.006). Clamping of the celiac and/or mesenteric arteries during surgery (n = 6) resulted in an almost 4 times higher PLI compared with not clamping these arteries (P = 0.001). In general linear models, the elevated PLI was particularly associated with suprarenal and celiac/mesenteric artery surgery, independently of aortic camping time and transfusion of blood products, even though the PLI directly correlated with aortic clamping time and number of red blood cell concentrates transfused (P = 0.031 or less). CONCLUSIONS: This study suggests that hepatosplanchnic rather than lower body/leg ischemia/reperfusion is a major risk factor for pulmonary vascular injury, associated with aortic surgery and independent of clamping time and transfusion of blood products.
    [Abstract] [Full Text] [Related] [New Search]