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  • Title: Can rheumatoid arthritis responsiveness to methotrexate and biologics be predicted?
    Author: Bansard C, Lequerré T, Daveau M, Boyer O, Tron F, Salier JP, Vittecoq O, Le-Loët X.
    Journal: Rheumatology (Oxford); 2009 Sep; 48(9):1021-8. PubMed ID: 19483089.
    Abstract:
    This review briefly recapitulates the existing markers predictive of RA responsiveness to treatment, focusing on MTX alone or combined with a biologic. In addition to the demographic and clinical factors, an update is provided of the predictive biomarkers identified by large-scale gene and protein analyses that generated new insights into the ability of high-throughput analysis of biological systems to select new potential indicators. Among the large-scale analysis tools now available, pharmacogenetics and pharmacogenomics (including transcriptomic and proteomic approaches) have been shown to provide such new putative biomarkers of therapeutic responses.
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