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  • Title: Synthesis and antimicrobial activity of some 5-substituted-3-phenyl-Nbeta-(substituted-2-oxo-2H-pyrano[2,3-b]quinoline-3-carbonyl)-1H-indole-2-carboxyhydrazide.
    Author: Suliphal Devara Mathada B, Bennikallu Hire Mathada M.
    Journal: Chem Pharm Bull (Tokyo); 2009 Jun; 57(6):557-60. PubMed ID: 19483333.
    Abstract:
    Ethyl 3-oxo-3-{2-[(5-substituted-3-phenyl-1H-indol-2-yl)carbonyl]hydrazinyl}propanoates 5a-b were synthesized according to the literature method. These on further reaction with substituted-2-hydroxy-3-formylquinolines 3a-e yielded 5-substituted-N(beta)-(2-oxo-2H-pyrano[2,3-b]quinoline-3-carbonyl)-3-phenyl-1H-indole-2-carbohydrazides 6a-j. Structures of the all the newly synthesized compounds were confirmed by spectral data. All these compounds have been screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilus, antifungal activity against Aspergillus niger and Candida albicans and antituberculosis activity against Mycobacterium tuberculosis (H37R(v)).
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