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  • Title: The high rate of adverse drug events in children receiving prolonged outpatient parenteral antibiotic therapy for osteomyelitis.
    Author: Faden D, Faden HS.
    Journal: Pediatr Infect Dis J; 2009 Jun; 28(6):539-41. PubMed ID: 19483522.
    Abstract:
    Forty-five children treated with 82 courses of 15 different antibiotics over 344 weeks during outpatient parenteral antibiotic therapy were evaluated for adverse drug events (ADE). Fifty-one percent of the courses had an associated ADE and 32.5% of the antibiotic courses were discontinued because of ADE. Vancomycin had the highest ADE rate at 85.7% and ceftriaxone had the highest ADE-related discontinuation rate at 66.7%. Cefazolin had the lowest rate of ADE and ADE-related discontinuation rates at 0% for both.
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