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  • Title: Phase-I study MEDI-534, of a live, attenuated intranasal vaccine against respiratory syncytial virus and parainfluenza-3 virus in seropositive children.
    Author: Gomez M, Mufson MA, Dubovsky F, Knightly C, Zeng W, Losonsky G.
    Journal: Pediatr Infect Dis J; 2009 Jul; 28(7):655-8. PubMed ID: 19483659.
    Abstract:
    A live, attenuated respiratory syncytial virus and parainfluenza virus type 3 vaccine was evaluated in healthy respiratory syncytial virus/parainfluenza virus type 3 seropositive children aged 1 to 9 years. Three cohorts of 40 children were randomized 1:1 to receive 10, 10, or 10 median tissue culture infectious dose50 MEDI-534 vaccine or placebo. The vaccine's safety profile was similar to placebo, no viral shedding was detected, and the vaccine was minimally immunogenic.
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