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  • Title: Mechanisms of therapeutic effects of granulocytic colony-stimulating factor in experimental diabetes mellitus.
    Author: Gol'dberg ED, Dygai AM, Zhdanov VV, Zyuz'kov GN, Ermakova NN, Vetoshkina TV, Fomina TI, Ermolaeva LA, Dubskaya TY.
    Journal: Bull Exp Biol Med; 2008 Oct; 146(4):543-6. PubMed ID: 19489338.
    Abstract:
    We studied the mechanisms of therapeutic effects of granulocytic colony-stimulating factor in experimental diabetes mellitus. It was found that this preparation increased the number of mesenchymal precursor cells in the bone marrow and peripheral blood with subsequent increase in the content of progenitor cells in the pancreas. These results attest to mobilization of mesenchymal progenitor cells and their migration into the damaged tissue accompanied by morphofunctional recovery of the insulin-producing apparatus.
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