These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of serum of patients with MODS on TF and PAI-1 secretion of human vascular endothelial cells during CRRT].
    Author: Wang JW, Peng YM, Liu FY, Zhang H.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2009 Jun; 25(6):534-6. PubMed ID: 19500510.
    Abstract:
    AIM: To elucidate the effects of serum of patients with multiple organ dysfunction syndrome (MODS) on tissue factor (TF) and Plasminogen activator inhibitor-1 (PAI-1) secretion of human vascular endothelial cells(HUVEC)during continuous renal replacement therapy (CRRT). METHODS: Sixteen patients who diagnosed MODS involved were divided into two groups randomly, eight patients treated with CRRT without heparin and the others with heparin for 8 hours. The blood was collected from patients at 0 min, 15 min, 60 min, 120 min and 480 min during CRRT. Serum TNF-alpha, IL-1beta were measured by ELISA.TF and PAI-1 secretion of HUVEC stimulated with serum of patients with MODS undergoing CRRT were detected. TF and PAI-1 expression level were assayed by RT-PCR. RESULTS: TF and PAI-1 secretion were significantly increased in HUVEC stimulated with serum of patients with MODS, but the levels were decreased after CRRT. There are significant positive correlation between TF or PAI-1 secretion of HUVEC and corresponding serum TNFalpha level in the group without heparin, the coefficient correlation is 0.902 and 0.939(P<0.05)respectively. But there are not significant correlation(P>0.05)in the group with heparin. CONCLUSION: Serum of patients with MODS promote the secretion of TF and PAI-1 in HUVEC.The dysfunction of HUVEC induced by serum of patients with MODS may be related to mediators of inflammation. CRRT can clean up the component which injure HEVEC and improve endothelial cell functions.
    [Abstract] [Full Text] [Related] [New Search]