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  • Title: [Insulin treatment in children].
    Author: Birkebaek NH, Hertz B, Olsen BS.
    Journal: Ugeskr Laeger; 2009 Jun 01; 171(23):1919-22. PubMed ID: 19500514.
    Abstract:
    Improving the diabetes metabolic regulation decreases the risk of microvascular diabetic complications. Insulin treatment in children therefore tends to be intensified to multiple-dose insulin (MDI) or continuous subcutaneous insulin injection (CSII). Further, insulin analogues are increasingly used. The pharmacokinetics of human and analogue insulin are summarised. It is concluded that pharmacokinetic studies on analogue insulin in children are required. Yet, no clear evidence of improved glycaemic control of the intensified treatment regimes has been shown in children. Long-term randomised studies are needed.
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