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  • Title: Comparability of ELISA and toxin neutralization to measure immunogenicity of Protective Antigen in mice, as part of a potency test for anthrax vaccines.
    Author: Parreiras PM, Sirota LA, Wagner LD, Menzies SL, Arciniega JL.
    Journal: Vaccine; 2009 Jul 16; 27(33):4537-42. PubMed ID: 19501205.
    Abstract:
    Complexities of lethal challenge models have prompted the investigation of immunogenicity assays as potency tests of anthrax vaccines. An ELISA and a lethal toxin neutralization assay (TNA) were used to measure antibody response to Protective Antigen (PA) in mice immunized once with either a commercial or a recombinant PA (rPA) vaccine formulated in-house. Even though ELISA and TNA results showed correlation, ELISA results may not be able to accurately predict TNA results in this single immunization model.
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