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  • Title: Structure-activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads.
    Author: Shah BA, Kaur R, Gupta P, Kumar A, Sethi VK, Andotra SS, Singh J, Saxena AK, Taneja SC.
    Journal: Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4394-8. PubMed ID: 19501509.
    Abstract:
    Analogues of parthenin were synthesized by substitutions at different reaction centres to establish a structure-activity relationship (SAR). Some of the molecules have displayed significant cytotoxicity in human cervical carcinoma (HeLa) and human myeloid leukemia (HL-60) cells. A few of the compounds also induced apoptosis in HL-60 cells measured in terms of sub-Go/G1 DNA fraction. Also one of the lead molecules has been shown to be the inhibitor of both telomerase and topoisomerase-II.
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