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  • Title: [Use of preventive intra-operative antibiotic administration in appendectomy. A pharmacokinetic study].
    Author: Adamek L, Mayer F, Wolf R, Raguse T.
    Journal: Zentralbl Chir; 1991; 116(13):801-8. PubMed ID: 1950215.
    Abstract:
    Studies on Cefazedone-kinetics in serum and subcutaneous fat tissue showed an early and lasting tissue concentration high above minimal inhibitation concentrations so that intraoperative single-shot administration of antibiotics are proven to be effective. Due to these pharmacokinetic patterns the results of an earlier prospective trial is confirmed that single-shot antibiotics during surgery are useful to reduce postoperative wound sepsis rate after appendectomy.
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