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  • Title: The use of sildenafil to treat portopulmonary hypertension prior to liver transplantation.
    Author: Cadden IS, Greanya ED, Erb SR, Scudamore CH, Yoshida EM.
    Journal: Ann Hepatol; 2009; 8(2):158-61. PubMed ID: 19502663.
    Abstract:
    Portopulmonary hypertension (PPH) is an infrequent, but well-recognized complication of liver cirrhosis. PPH in those with end-stage liver disease has a significant impact on per-operative and intra-operative mortality, with liver transplantation being contraindicated in those individuals with mean pulmonary artery pressure exceeding 50 mmHg. Vasodilatory therapy is the mainstay of pharmacotherapy for PPH, although the evidence of benefit is largely extrapolated from the pulmonary hypertension literature. We report the use of the phosphodiesterase inhibitor, sildenafil, in a patient with end stage liver disease and PPH, with a pulmonary artery pressure before transplantation of 75 mmHg, to reduce pulmonary artery pressure prior to a successful liver transplant.
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