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  • Title: Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.
    Author: Dai SJ, Peng WB, Shen L, Zhang DW, Ren Y.
    Journal: J Asian Nat Prod Res; 2009; 11(5):451-6. PubMed ID: 19504388.
    Abstract:
    Two new neo-clerodane diterpenoid alkaloids, scutebarbatine O (1) and 6-O-nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1 and 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 2.1-5.7 microM.
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