These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Study on the antidiabetic mechanism of a shark liver peptide, S-8300, in alloxan-induced diabetes.
    Author: Huang F, Wu W.
    Journal: J Pharm Pharmacol; 2009 Jun; 61(6):789-94. PubMed ID: 19505370.
    Abstract:
    OBJECTIVES: The aim was to evaluate the antidiabetic mechanism of S-8300 in alloxan-diabetic mice. METHODS: Diabetes was induced by a single intravenous injection of alloxan (60 mg/kg). The effects of S-8300 on diabetic mice were investigated by observing the change in fasting plasma glucose, detecting Fas mRNA by reverse transcriptase-polymerase chain reaction, Fas protein expression in the pancreas by immunohistochemistry and Western blot, and the DNA fragmentation pattern forming a ladder by electrophoresis. KEY FINDINGS: A significant decrease in fasting plasma glucose was observed, and Fas mRNA and Fas protein expression in the pancreas were attenuated in diabetic mice treated with S-8300. Treatment with S-8300 also attenuated DNA ladder formation. CONCLUSIONS: The results suggest that S-8300 inhibits Fas protein-mediated apoptosis of pancreas cells.
    [Abstract] [Full Text] [Related] [New Search]