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  • Title: Fatal nephrotic syndrome complicating allogeneic stem cell transplantation: a case report.
    Author: Ben-Dov IZ, Pizov G, Ben-Chetrit E, Rubinger D, Or R.
    Journal: Nephrol Dial Transplant; 2009 Sep; 24(9):2946-9. PubMed ID: 19506045.
    Abstract:
    Disturbed kidney function is a common occurrence after bone-marrow transplantation. Sepsis, nephrotoxic medications, thrombotic microangiopathy and injury related to haemodynamic alterations are frequently accountable. Recently, attention has been given to immune-mediated glomerular damage, related to graft-versus-host disease. Herein we describe the fatal course of a nephrotic syndrome complicating allogeneic stem cell transplantation in a young woman with long-standing paroxysmal nocturnal haemoglobinuria. A post-mortem kidney biopsy revealed amyloidosis of the AA type. Physicians should be aware of the possibility that infections and inflammation accompanying the post-transplantation period may rarely promote the development of systemic amyloidosis or exacerbate silent pre-existing disease.
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