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  • Title: How seizure detection by continuous electroencephalographic monitoring affects the prescribing of antiepileptic medications.
    Author: Kilbride RD, Costello DJ, Chiappa KH.
    Journal: Arch Neurol; 2009 Jun; 66(6):723-8. PubMed ID: 19506131.
    Abstract:
    OBJECTIVES: To assess the effect of continuous electroencephalographic monitoring on the decision to treat seizures in the inpatient setting, particularly in the intensive care unit. DESIGN: Retrospective cohort study. SETTING: Medical and neuroscience intensive care units and neurological wards. PATIENTS: Three hundred consecutive nonelective continuous electroencephalographic monitoring studies, performed on 287 individual inpatients over a 27-month period. MAIN OUTCOME MEASURES: Epileptiform electroencephalographic abnormalities and changes in antiepileptic drug (AED) therapy based on the electroencephalographic findings. RESULTS: The findings from the continuous electroencephalographic monitoring led to a change in AED prescribing in 52% of all studies with initiation of an AED therapy in 14%, modification of AED therapy in 33%, and discontinuation of AED therapy in 5% of all studies. Specifically, the detection of electrographic seizures led to a change in AED therapy in 28% of all studies. CONCLUSIONS: The findings of continuous electroencephalographic monitoring resulted in a change in AED prescribing during or after half of the studies performed. Most AED changes were made as a result of the detection of electrographic seizures.
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