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  • Title: Herpesvirus saimiri-induced lymphoproliferative disease in howler monkeys.
    Author: Rangan SR, Martin LN, Enright FM, Abee CR.
    Journal: J Natl Cancer Inst; 1977 Jul; 59(1):165-71. PubMed ID: 195067.
    Abstract:
    Four of 5 howler monkeys (Alouatta caraya) experimentally infected with Herpesvirus saimiri (HVS) developed a rapidly fatal malignant lymphoma accompanied by peripheral T-cell lymphocytosis. HVS was isolated from fresh and tissue cultured blood and tissue lymphocytes and from cell cultures derived from nonlymphoid organs. Humoral antibodies against HVS-induced antigens were detected in the sera of the animals. The in vitro response of the peripheral blood lymphocytes to mitogenic stimulants was depressed following HVS infection.
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