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  • Title: A case of sulphasalazine-induced DRESS syndrome with delayed acute interstitial nephritis.
    Author: Augusto JF, Sayegh J, Simon A, Croue A, Chennebault JM, Cousin M, Subra JF.
    Journal: Nephrol Dial Transplant; 2009 Sep; 24(9):2940-2. PubMed ID: 19509026.
    Abstract:
    Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a rare and severe drug-induced hypersensitivity syndrome characterized by haematological abnormalities (hypereosinophilia and/or mononucleosis) and multiorgan involvement. Renal failure has been rarely described. We report the case of a 77-year-old female with sulphasalazine-induced DRESS syndrome who improved rapidly on corticosteroid treatment. After prednisone withdrawal, the patient developed renal failure that necessitated a session of haemodialysis. A kidney biopsy showed acute tubulointerstitial nephritis with an intense lymphocytic infiltrate and tubular necrosis. Kidney function normalized after a further 2 weeks of corticosteroid treatment. This is the first histologically proven case of acute tubulointerstitial nephritis in the setting of sulphasalazine-induced DRESS syndrome.
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