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  • Title: Elemental diet in steroid-dependent and steroid-refractory Crohn's disease.
    Author: O'Brien CJ, Giaffer MH, Cann PA, Holdsworth CD.
    Journal: Am J Gastroenterol; 1991 Nov; 86(11):1614-8. PubMed ID: 1951239.
    Abstract:
    Sixteen patients with Crohn's disease who had symptoms uncontrolled by high-dose steroids (n = 11) or symptoms invariably appearing on reduction or withdrawal of immunosuppressive therapy (n = 5) were treated with elemental diet. After 4 wk of dietary treatment, 10 patients were in remission and off all medication. Seven continued to be well without treatment for a minimum of 6 months, and four for at least 1 yr. No patient who subsequently relapsed had further steroid-refractory symptoms. Of the six patients failing to respond to elemental diet, four with steroid-refractory disease required early resective surgery for symptom relief, and two continued with steroid therapy, one in much reduced dosage. Elemental diet can bring about a sustained remission in many patients with Crohn's disease dependent on or refractory to corticosteroids, and reduce the need for surgical intervention.
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