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  • Title: Sulfasalazine-induced hypersensitivity syndrome in a 15-year-old boy associated with human herpesvirus-6 reactivation.
    Author: Balci DD, Peker E, Duran N, Dogramaci CA.
    Journal: Cutan Ocul Toxicol; 2009; 28(1):45-7. PubMed ID: 19514926.
    Abstract:
    Drug-induced hypersensitivity syndrome (DIHS) is characterized by high fever, facial edema, diffuse maculopapular eruption, and multiorgan involvement. Human herpesvirus (HHV)-6 reactivation is an accepted criterion for the diagnosis of DIHS and has prognostic importance. We report a 15-year-old boy with juvenile rheumatoid arthritis who developed DIHS due to sulfasalazine, associated with reactivation of HHV-6.
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