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  • Title: Dipeptidyl nitrile inhibitors of Cathepsin L.
    Author: Asaad N, Bethel PA, Coulson MD, Dawson JE, Ford SJ, Gerhardt S, Grist M, Hamlin GA, James MJ, Jones EV, Karoutchi GI, Kenny PW, Morley AD, Oldham K, Rankine N, Ryan D, Wells SL, Wood L, Augustin M, Krapp S, Simader H, Steinbacher S.
    Journal: Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4280-3. PubMed ID: 19515558.
    Abstract:
    A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.
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