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  • Title: Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
    Author: Hart T, Macias AT, Benwell K, Brooks T, D'Alessandro J, Dokurno P, Francis G, Gibbons B, Haymes T, Kennett G, Lightowler S, Mansell H, Matassova N, Misra A, Padfield A, Parsons R, Pratt R, Robertson A, Walls S, Wong M, Roughley S.
    Journal: Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4241-4. PubMed ID: 19515560.
    Abstract:
    We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.
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