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  • Title: M2, M3, and M4 muscarinic receptors are expressed in the guinea pig gallbladder.
    Author: Cabadak H, Cuadra AE, El-Fakahany EE, Kan B.
    Journal: J Recept Signal Transduct Res; 2009; 29(1):63-6. PubMed ID: 19519171.
    Abstract:
    AIM: The identity of muscarinic acetylcholine receptors (mAchR) involved in cholinergic-mediated contraction of the guinea pig gallbladder has been a matter of debate. Different groups have suggested the involvement of M(1), M(2), M(3), or M(4) receptor subtypes in the contraction of this tissue. The objective of this study was to identify the mAchR subtypes expressed in the guinea pig gallbladder by RT-PCR. METHODS: Total RNA prepared from frozen guinea pig gallbladder tissue was amplified by using specific primers for the M(1)-M(4) receptor subtypes. RESULTS: M(2), M(3), and M(4) transcripts were detected in the following rank order: M(4) > M(2) > M(3). We were unable to demonstrate the expression of the M(1) receptor subtype in this tissue. CONCLUSIONS: Our results are in agreement with our previous binding and functional data.
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