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  • Title: Fluorophotometric evaluation of experimental blood-aqueous barrier disruption in dogs.
    Author: Ward DA, Ferguson DC, Kaswan RL, Green K, Bellhorn RW.
    Journal: Am J Vet Res; 1991 Sep; 52(9):1433-7. PubMed ID: 1952328.
    Abstract:
    A protocol for performing slit-lamp fluorophotometry of the anterior chamber in dogs was established. The technique was then used to develop a model of blood-aqueous barrier disruption that can be used for comparative testing of ophthalmic anti-inflammatory drugs. It was determined that barrier disruption induced by a slow, controlled paracentesis of a small volume of aqueous humor may provide the most reliable model for drug testing. Additionally, fluorophotometry proved to be a sensitive and accurate means of detecting breakdown of the blood-aqueous barrier.
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