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  • Title: Pharmacokinetics and synovial fluid concentrations of cephapirin in calves with suppurative arthritis.
    Author: Brown MP, Gronwall RR, Pattio N, Poulos PW, Houston AE.
    Journal: Am J Vet Res; 1991 Sep; 52(9):1438-40. PubMed ID: 1952329.
    Abstract:
    Six calves with suppurative arthritis were given a single IM injection of sodium cephapirin at a dosage of 10 mg/kg of body weight. Cephapirin concentrations were serially measured in serum and in normal and suppurative synovial fluid over a 24-hour period. Mean peak serum concentration was 6.33 microliters/ml at 20 minutes after injection. The highest cephapirin concentrations in normal and suppurative synovial fluid were 1.68 and 1.96 micrograms/ml, respectively, 30 minutes after injection. Overall mean cephapirin concentration in normal synovial fluid for the first 4 hours (1.04 +/- 0.612 micrograms/ml) was not significantly different from that in suppurative synovial fluid (0.88 +/- 0.495 micrograms/ml; P greater than 0.05). Elimination half-life was 0.60 hours and clearance was 1,593 ml/h/kg.
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