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  • Title: Fabrication of porous gelatin microfibers using an aqueous wet spinning process.
    Author: Yang CY, Chiu CT, Chang YP, Wang YJ.
    Journal: Artif Cells Blood Substit Immobil Biotechnol; 2009; 37(4):173-6. PubMed ID: 19526441.
    Abstract:
    Alginate has a unique property of gel formation by chelating with divalent cations such as Ca(+2) in aqueous solution. The sol-gel characteristic of alginate has been utilized to fabricate both microsphere and microcapsule for cell immobilization. In this study, a wet spinning process was employed to prepare fibers comprised of gelatin and sodium alginate. Gelatin fibers containing interconnected porous structure were fabricated by the extraction of alginate from these gelatin/alginate composite fibers with phosphate buffer. The application of these porous gelatin fibers for enzyme immobilization was demonstrated by its usage as the base material of glucose biosensor.
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