These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Preadmission use of systemic glucocorticoids and 30-day mortality following bleeding peptic ulcer: a population-based cohort study.
    Author: Olsen M, Christensen S, Riis A, Thomsen RW.
    Journal: Am J Ther; 2010; 17(1):23-9. PubMed ID: 19531935.
    Abstract:
    Systemic glucocorticoid use is associated with an increased risk for peptic ulcer bleeding (PUB); however, little is known about whether glucocorticoid use is associated with PUB outcome. We conducted a population-based cohort study to examine the association between preadmission use of systemic glucocorticoids and 30-day mortality following PUB. We identified all patients (n = 7,486) hospitalized with a first-time diagnosis of PUB in Western Denmark between 1991 and 2004. Data on PUB; systemic glucocorticoid use (n = 574; 7.7%), including cumulative dose; use of other ulcer-related drugs; previous uncomplicated ulcer; comorbidities; and complete follow-up for mortality were obtained from population-based medical databases. We computed 30-day mortality and mortality rate ratios (MRRs) comparing glucocorticoid users and nonusers, controlling for potential confounding factors. Thirty-day mortality was 14.0% among users of systemic glucocorticoids and no other ulcer-related drugs and 8.7% among nonusers of glucocorticoids, corresponding to an adjusted MRR of 1.30 (95% confidence interval [CI], 0.81-2.08). Among users of systemic glucocorticoids in combination with other ulcer-related drugs, 30-day mortality was 18.9%, corresponding to an adjusted MRR of 1.54 (95% CI, 1.20-1.99). Among both short-term and long-term users, high-dose glucocorticoid use was associated with a greater increase in mortality than low-dose use. Former use of systemic glucocorticoids was not associated with increased mortality. Thus, preadmission use of systemic glucocorticoids was associated with increased 30-day mortality following PUB. Increased mortality was most pronounced when glucocorticoids were used in high doses or were combined with other ulcer-related drugs.
    [Abstract] [Full Text] [Related] [New Search]