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  • Title: Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".
    Author: Méndez-Ardoy A, Gómez-García M, Ortiz Mellet C, Sevillano N, Girón MD, Salto R, Santoyo-González F, García Fernández JM.
    Journal: Org Biomol Chem; 2009 Jul 07; 7(13):2681-4. PubMed ID: 19532982.
    Abstract:
    Gene delivery systems based on the beta-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling ("click chemistry") and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the click approach.
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