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  • Title: Nanomechanical contrasts of gel and fluid phase supported lipid bilayers.
    Author: Goertz MP, Stottrup BL, Houston JE, Zhu XY.
    Journal: J Phys Chem B; 2009 Jul 09; 113(27):9335-9. PubMed ID: 19534482.
    Abstract:
    Lipid bilayers exhibit structural diversity that contributes to the complex properties of the cell membrane. We use interfacial force microscopy to correlate mechanical properties with the two-dimensional phase behavior of supported lipid bilayers (SLBs). Upon indentation by a 500 nm tungsten tip, a contrast in the mechanical response is observed for gel vs fluid phase SLBs. We measure the yield force and time scale for recovery for these films. Consistent with a gel phase, a DSPC SLB has a relatively high yield force and slow recovery. In the higher mobility fluid phase, a DLPC SLB has a lower yield force and completely recovers within the experimental time scale. Friction measurements offer further contrast between the two SLBs.
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