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  • Title: Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells.
    Author: Qiu YK, Dou DQ, Cai LP, Jiang HP, Kang TG, Yang BY, Kuang HX, Li MZ.
    Journal: Fitoterapia; 2009 Jun; 80(4):219-22. PubMed ID: 19535014.
    Abstract:
    A new compound, named quinquefoloside-L(c) (1), together with nine known compounds, was isolated from leaves of Panax quinquefolium, and its structure was elucidated as 3beta,12beta, 20S-trihydroxy-25-methoxydammar-23-ene 3-O-beta-D-glucopyranosyl (1-->2)beta-D-glucopyranosyl-20-O-beta-D-xylopyanosyl (1-->6) beta-D-glucopyranoside (1), on the basis of MS, 1D-and 2D-NMR experiments as well as by chemical degradation. The cytotoxicity of these compounds against human breast cancer MCF-7 cell line was also tested by MTT method.
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