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  • Title: POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report.
    Author: Bosco J, Pathmanathan R.
    Journal: Aust N Z J Med; 1991 Aug; 21(4):454-6. PubMed ID: 1953537.
    Abstract:
    Peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes are often the presenting features of the POEMS syndrome. Approximately 50% of these are associated with osteosclerotic myeloma, a rare variant of multiple myeloma and some with Castleman's disease, an unusual lympho-proliferative disorder. The underlying pathogenetic mechanisms have not been elucidated but amelioration of symptoms with the disappearance of the M-component suggests possible etiopathogenic mechanisms. We present a 40-year-old woman with manifestations of all three disorders.
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