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  • Title: Adult fulminant subacute sclerosing panencephalitis: pathological and molecular studies--a case report.
    Author: Souraud JB, Faivre A, Waku-Kouomou D, Gaillard T, Aouad N, Meaudre E, Wild FT, Fouet B, Soulard R.
    Journal: Clin Neuropathol; 2009; 28(3):213-8. PubMed ID: 19537141.
    Abstract:
    Subacute sclerosing panencephalitis is an uncommon progressive neurological disorder caused by a persistent defective measles virus, typically affecting children. We describe a case of fulminant subacute sclerosing panencephalitis in a 25-year-old male. Brain tissue biopsy showed histologic evidence of encephalitis with eosinophilic intranuclear inclusion bodies (Cowdry Type A and B), intracytoplasmic inclusion bodies, perivascular lymphoplasmacytic infiltration and gliosis. Immunohistochemical studies were positive using an anti-measles antibody. Reverse transcriptase-PCR detected measles virus RNA and phylogenetic analysis indicated a C2 genotype. The rare adult-onset form is often atypical and difficult to diagnose and should be included in the differential diagnosis of subacute "unexplained" neurological diseases and uncommon infectious disorders.
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