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  • Title: The use of tannins to control Salmonella typhimurium infections in pigs.
    Author: Van Parys A, Boyen F, Dewulf J, Haesebrouck F, Pasmans F.
    Journal: Zoonoses Public Health; 2010 Sep; 57(6):423-8. PubMed ID: 19538452.
    Abstract:
    The aim of this study was to determine whether a hydrolysable tannin extract of sweet chestnut wood (Globatan(®)) has an inhibitory effect on Salmonella Typhimurium survival both in vitro and in vivo in pigs. In a first experiment, the minimal inhibitory concentration of Globatan(®) on 57 Salmonella Typhimurium isolates was determined. For all isolates, an MIC of 160-320 μg/ml was found. The second in vitro study revealed that Salmonella growth was strongly reduced using Globatan(®) concentrations of 25-50 μg/ml and nearly completely inhibited at a concentration of 100 μg/ml Globatan(®). In an in vivo trial, two groups of six piglets, each group receiving feed with or without the addition of Globatan(®) (3 g/kg), were orally inoculated with 10(7) colony forming units of a Salmonella Typhimurium strain. Globatan(®) had no effect on faecal excretion of Salmonella, and no differences in colonization of the intestines and internal organs were demonstrated in pigs euthanized at 4 days post-inoculation. In conclusion, the hydrolysable tannin extract used in this study showed strong action against Salmonella Typhimurium in vitro but not in vivo.
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