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  • Title: In vitro synergistic effects of metergoline and antifungal agents against Candida krusei.
    Author: Kang K, Wong KS, Seneviratne CJ, Samaranayake LP, Fong WP, Tsang PW.
    Journal: Mycoses; 2010 Nov; 53(6):495-9. PubMed ID: 19538518.
    Abstract:
    Metergoline, a serotonin receptor antagonist, was evaluated for its antifungal activity against the opportunistic human fungal pathogen Candida krusei by a broth microdilution assay. The minimal inhibitory concentration and minimal fungicidal concentration of metergoline against C. krusei were 4 and 8 μg ml(-1) respectively. Significant synergism was found in combination of metergoline with amphotericin B (fractional inhibitory concentration index: 0.375-0.5) by a chequerboard assay. Metergoline also inhibited extracellular phospholipase secretion in a dose-dependent manner, which may be a possible action mechanism of metergoline on C. krusei.
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