These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: 3D model of amphioxus steroid receptor complexed with estradiol.
    Author: Baker ME, Chang DJ.
    Journal: Biochem Biophys Res Commun; 2009 Aug 28; 386(3):516-20. PubMed ID: 19540191.
    Abstract:
    The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates. To investigate the evolution of estrogen-binding to steroid receptors, we constructed a 3D model of amphioxus SR complexed with estradiol. This 3D model indicates that although the SR is activated by estradiol, some interactions between estradiol and human ERalpha are not conserved in the SR, which can explain the low affinity of estradiol for the SR. These differences between the SR and ERalpha in the steroid-binding domain are sufficient to suggest that another steroid is the physiological regulator of the SR. The 3D model predicts that mutation of Glu-346 to Gln will increase the affinity of testosterone for amphioxus SR and elucidate the evolution of steroid-binding to nuclear receptors.
    [Abstract] [Full Text] [Related] [New Search]