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  • Title: A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge.
    Author: Rouxel RN, Svitek N, von Messling V.
    Journal: Vaccine; 2009 Aug 06; 27(36):4961-6. PubMed ID: 19540272.
    Abstract:
    CDV infects a broad range of carnivores, and over the past decades it has caused outbreaks in a variety of wild carnivore populations. Since the currently available live-attenuated vaccine is not sufficiently safe in these highly susceptible species, we produced a chimeric virus combining the replication complex of the measles Moraten vaccine strain with the envelope of a recent CDV wild type isolate. The resulting virus did not cause disease or immunosuppression in ferrets and conferred protection from challenge with a lethal wild type strain, demonstrating its potential value for wildlife conservation efforts.
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