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  • Title: Ribosome inactivating proteins of plants.
    Author: Lord JM, Hartley MR, Roberts LM.
    Journal: Semin Cell Biol; 1991 Feb; 2(1):15-22. PubMed ID: 1954339.
    Abstract:
    Many plant tissues produce single chain proteins which can enzymatically remove a specific adenine residue from ribosomal RNA. Although these proteins are potently toxic to isolated ribosomes, they are non-toxic to intact cells, being unable to gain access to their ribosomal substrate. In certain plants however, the gene for the ribosome inactivating protein has fused with a gene encoding a galactose-specific lectin. This generates heterodimeric proteins which can bind to and enter target cells, and which are among the most potent cytotoxins known.
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