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  • Title: Alleviating the ischemia-reperfusion injury of donor liver by transfection of exogenous hTERT genes.
    Author: Wang W, Liu CZ, Jin B, Hu SY, Liu XX, Jiang XS, Zhang ZL, Zhu M.
    Journal: Transplant Proc; 2009 Jun; 41(5):1499-503. PubMed ID: 19545665.
    Abstract:
    BACKGROUND: Ischemia-reperfusion (I/R) injury had been linked to primary graft dysfunction in transplantation. To find effective methods to alleviate donor liver injury from I/R, we transferred exogenous human telomerase reverse transcriptase (hTERT) genes into donor rats before liver transplantation. METHODS: SD rats (age, 16 months) were divided into 3 groups: group A were donors pretreated with exogenous hTERT gene; group B were donors pretreated with adenovirus vector only; and group C were donors pretreated with physiologic saline. Alanine aminotransferase (ALT), apoptotic index, telomerase activity, and histological evaluation were calculated after liver transplantation. RESULTS: The levels of ALT and apoptotic index of group A were significantly lower than those of group B or group C (P < .05), at the same time, a mild histological injury and increased telomerase activity were also observed in group A. CONCLUSIONS: Exogenous hTERT gene provides protection against I/R injury, which depends on exogenous hTERT gene-mediated inhibition of apoptosis.
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