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  • Title: The risk of a second diagnostic window with 4th generation HIV assays: Two cases.
    Author: Niederhauser C, Ströhle A, Stolz M, Müller F, Tinguely C.
    Journal: J Clin Virol; 2009 Aug; 45(4):367-9. PubMed ID: 19546027.
    Abstract:
    BACKGROUND: Despite the improved sensitivity of the 4th generation combined antigen/antibody HIV assays, detection of HIV in the early phase of an infection may still be ineffective. OBJECTIVES: Description of two cases that highlight the existence of the "second diagnostic window phase" observed with commonly used sensitive 4th generation HIV assays. STUDY DESIGN: Samples were screened with different 4th generation HIV assays. HIV infection was confirmed with an HIV I/II antibody assay, a HIV-1 p24 antigen assay, the INNO-LIA HIV I/II Score Line immunoassay and HIV-1 PCR. RESULTS: In both investigated cases, the limitations of the 4th generation HIV assays within the second diagnostic window were apparent. CONCLUSIONS: The overall sensitivity of the commercial 4th generation HIV assays is currently higher than the 3rd generation HIV assays. Nevertheless, the rare occurrence of a second diagnostic window with 4th generation HIV assays strongly suggests that the following up testing algorithms need to be adjusted accordingly.
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