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  • Title: Peroxisome proliferator-activated receptor gamma agonists in kidney disease--future promise, present fears.
    Author: Mao Z, Ong AC.
    Journal: Nephron Clin Pract; 2009; 112(4):c230-41. PubMed ID: 19546582.
    Abstract:
    The peroxisome proliferator-activated receptor superfamily (PPARs) comprises a class of nuclear receptors with significant effects in regulating multiple cellular pathways. Much research and clinical interest has surrounded the PPAR-gamma isoform because of its key role in the transcriptional regulation of metabolic pathways and the efficacy of thiazolidinediones, the most clinically used PPAR-gamma agonist, in the management of type 2 diabetes mellitus. In this review, we discuss the pathogenic role of PPAR-gamma in experimental models of kidney disease, clinical trials of thiazolidinediones in diabetic and non-diabetic kidney disease, recent safety concerns surrounding PPAR-gamma agonists and reflect on their potential use in 'orphan' kidney diseases.
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